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Oxycodone was first made in Germany in 1916 from thebaine and It is available as a generic medication, but In 2018, it was the 48th most commonly prescribed medication in the United States, with more than 16 million prescriptions.

Several abuse-deterrent formulations are available, such as combining oxycodone with naloxone and naltrexone. Because it is a legal drug, Oxycodone is supplied across the country for legitimate medical purposes.

Word of mouth has allowed users to devise illicit usage techniques. Pharmacy robberies, health care fraud, and international trafficking constitute illicit distribution ability. When legally sold, a 10-mg tablet of Oxycodone will cost $1.25 and an 80-mg tablet will cost $6.

When illegally sold, a 10-mg tablet of Oxycodone can cost between $5.00 and $10.00. An 80-mg tablet can cost between $65.00 and $80.50.In the U.S., extended-release oxycodone is approved for use in children as young as eleven years old.

The approved uses are for the relief of cancer pain, trauma pain, or pain due to major surgery, in children already treated with opioids, who can tolerate at least 20 mg per day of oxycodone; this provides an alternative to Duragesic, the only other extended-release opioid analgesics approved for children.

In the US, oxycodone is only approved for use by mouth, available as tablets and oral solutions. In 2011, oxycodone was the leading cause of drug-related deaths in the U.S.However, from 2012 onwards, heroin and fentanyl have become more common causes of drug-related deaths.